Potential of Three Ethnomedicinal Plants as Antisickling Agents
نویسندگان
چکیده
منابع مشابه
Potential of Three Ethnomedicinal Plants as Antisickling Agents.
Sickle cell disease (SCD) is a genetic blood disorder that affects the shape and transportation of red blood cells (RBCs) in blood vessels, leading to various clinical complications. Many drugs that are available for treating the disease are insufficiently effective, toxic, or too expensive. Therefore, there is a pressing need for safe, effective, and inexpensive therapeutic agents from indigen...
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Modulation of immune response to alleviate diseases has long since been of interest. Recent progress on the ethnomedicinal plants as immunomodulatory agent reported from 2000 to early 2008 is reviewed. Plant extracts have been widely investigated in this time in different parts of the world for their possible immunomodulatory properties. Some of the studies demonstrated to the isolation of pote...
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Several aromatic compounds have been found to inhibit the gelling of sickle cell hemoglobin. We have tried to correlate the antigelling activity of such compounds with the stereo-chemistry of their binding sites in the hemoglobin molecule. This approach led to the discovery that two known antilipoproteinemia drugs, clofibrate and gemfibrozil, have antigelling activity. X-ray analysis showed tha...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2016
ISSN: 1543-8384,1543-8392
DOI: 10.1021/acs.molpharmaceut.6b00767